Big Impact in Bio: Identifying Biosignals to Improve Women’s Health

Jul 9, 2018 9:20 AM ET
Blog

From an early age, Suzanne Rohrback had a unique insight into the need for science to bridge gaps in medical care. Her big brother is autistic and growing up, Rohrback remembers thinking there were no good options for him – unmedicated, he could be unpredictably violent and medicated, he would be zombie-like. “But we don’t understand enough about what goes wrong in this condition to have created a better solution,” she says.

This early experience drove Rohrback down the path of using scientific knowledge to improve people’s quality of life. Now a scientist at genomics company Illumina in San Diego, she is working to identify biosignals in people’s blood that can help develop diagnostic tools for a range of reproductive health disorders.

A 2009 Amgen Scholars alumna, Rohrback recalls that her Amgen Scholars summer at the University of Washington was the first opportunity she had to do research full-time. That summer gave her the confidence to continue in research and eventually pursue her Ph.D. at University of California, San Diego, studying how changes in the DNA of individual cells arise during important periods of brain development and may be involved in disorders such as fetal alcohol syndrome.

It was there she discovered a love of bioinformatics – figuring out how to interpret the DNA sequencing data her lab was collecting – and she had the opportunity to collaborate with a team at Illumina. “When I mentioned to that group I was finishing my dissertation, I was lucky to hear that they had a job opening at the same time,” she says.

In her work at Illumina, Rohrback and colleagues recently completed a large clinical study in which they collected blood from more than 100 donors to “interrogate signals indicative of women’s health,” she says. “Not only did we detect differences reflecting their health status, but I was able to use that signal to build machine learning models that could accurately identify individuals with the same health complications in a completely different set of blood samples.”

This predictive ability could help develop new diagnostic and treatment options, including for noninvasive prenatal testing. “The knowledge that our work has the potential to directly contribute to the development of new clinical applications that can allow doctors to provide life-saving medical care inspires me every day,” she says.

One of the most rewarding parts of the work has been the collaboration with physicians at academic medical centers around the world, Rohrback says: “It’s been extremely validating to hear their excitement when sharing our recent findings with them. Their enthusiasm highlights the incredible potential of our work to make a difference in the lives of numerous women.”

Rohrback is greatly enjoying her work in the biotech industry but the transition from academia to industry has been an adjustment, she says: “Now I juggle benchwork and data analysis tasks on two primary projects, periodically assist my teammates on several others, and attend half a dozen meetings a week, several of which I also organize and/or present in. It’s an incredibly fast-paced environment, but it’s also incredible what our focus, determination, and teamwork can accomplish.”

She recalls a recent time in which concerns came up about quantifying the amount of blood needed to obtain a consistent measurement. “Our team mobilized immediately, and within three weeks we had generated and extensively analyzed the signal from over a hundred different blood samples, providing a definitive answer to the question – work that would have taken me months of effort working alone,” she says.

The Amgen Scholars Program gave her early in her career a taste of the possibilities within the biotech industry. “I gained much more perspective about how diverse the opportunities are in science research,” she says.

In thinking about advice to other Amgen Scholars, Rohrback says not to overlook the value of “soft skills.” An active member of the Healthcare Businesswomen’s Association, she recommends building a robust professional network and strong communications skills. “Effective communication skills are essential for being able to work effectively – and happily –with people who have different technical backgrounds and personalities.”