It can take longer to diagnose rare diseases than many common diseases. On average, rare disease diagnosis takes 7.6 years in the U.S. and 5.6 years in the UK. Rare diseases such as the primary immunodeficiency (PI) disorders Gaucher disease, Fabry disease, and Hunter syndrome can be devastating, as they are difficult to detect and equally difficult to treat. 60,000 Our U.S. patient assistance programs reached approximately 60,000 patients. We have 37 programs in clinical development, the most robust pipeline in Shire’s history.